Explains the effect of the COVID-19 pandemic on clinical research and provides suggestions for which studies should proceed, which should pivot to research on the pandemic, which should be paused, and which should stop.
Our analysis of data from FDA’s assessment of currently marketed angiotensin receptor blocker drugs, with regard to nitrosamine impurities
Analysis of comments to CMS from stakeholders regarding reimbursement for ambulatory blood pressure monitoring, often described as the gold standard blood pressure measurement method, but rarely used in the United States
We review the recent guidelines addressing the diagnosis and management of hypertension.
We provide insights into the effects of recent blood pressure medication recalls on patients, healthcare providers, and health systems.
mRNA is a critical biomolecule involved in the manifestation of the genetic code into functional protein molecules. Its critical role in the central dogma has made it a key target in many studies to determine biomarkers and drug targets for numerous diseases. Currently, there is a growing body of evidence to suggest that RNA molecules around the size of full-length mRNA transcripts can be assayed in the supernatant of human urine and urinary extracellular mRNA could provide information about transcription in cells of urogenital tissues. However, the optimal means of normalizing these signals is unclear. In this paper, we describe relevant first principles as well as research findings from our lab and other labs toward normalization of urinary extracellular mRNA.
Clinical research involving extracellular vesicles.
Analysis of the relationship between gene expression in the human renal cortex and urinary extracellular vesicles, as well as a study of intentional modulation of the renin-angiotensin-aldosterone system in humans with attention to corresponding changes in mRNA transcript abundance in the urine supernatant.
A pragmatic discussion of the diagnosis and treatment of primary aldosteronism.
Our and others’ research presented at the 2018 International Society for Extracellular Vesicles’ Biomarkers Workshop, Birmingham, UK.