Adrenal vein sampling lateralization despite mineralocorticoid receptor antagonists exposure in primary aldosteronism

**Context:** Many antihypertensive medications modulate the renin-angiotensin-aldosterone system, possibly skewing the diagnosis and subtyping of primary aldosteronism (PA). Particularly, mineralocorticoid receptor antagonists (MRA) might raise renin …

Human urinary mRNA as a biomarker of cardiovascular disease

Analysis of the relationship between gene expression in the human renal cortex and urinary extracellular vesicles, as well as a study of intentional modulation of the renin-angiotensin-aldosterone system in humans with attention to corresponding changes in mRNA transcript abundance in the urine supernatant.

Primary aldosteronism

A pragmatic discussion of the diagnosis and treatment of primary aldosteronism.

Summary of the ISEV workshop on extracellular vesicles as disease biomarkers, held in Birmingham, UK, during December 2017

Our and others' research presented at the 2018 International Society for Extracellular Vesicles' Biomarkers Workshop, Birmingham, UK.

Discordance between imaging and immunohistochemistry in unilateral primary aldosteronism

**OBJECTIVE:** Correct subtyping of primary aldosteronism (PA) is essential for good surgical outcomes. Adrenal vein sampling (AVS) and/or computed tomography (CT) are used for PA subclassification. Clinical and/or biochemical improvement after …

Aldosterone synthase promoter polymorphism and cardiovascular phenotypes in a large, multiethnic population-based study

**BACKGROUND:** A single-nucleotide polymorphism in the aldosterone synthase gene (CYP11B2) promoter [-344C/T, rs1799998] has been reported to associate with cardiovascular phenotypes. **METHODS:** The Dallas Heart Study is a large, multiethnic …

A critical review of the evidence supporting aldosterone in the etiology and its blockade in the treatment of obesity-associated hypertension

Obesity is epidemic and is associated with increased blood pressure, which often manifests as treatment-resistant hypertension. Mineralocorticoids have been hypothesized to have a pathogenic role in human obesity-associated hypertension. In this …