Primary aldosteronism

A pragmatic discussion of the diagnosis and treatment of primary aldosteronism.

Summary of the ISEV workshop on extracellular vesicles as disease biomarkers, held in Birmingham, UK, during December 2017

Our and others' research presented at the 2018 International Society for Extracellular Vesicles' Biomarkers Workshop, Birmingham, UK.

Serum cortisol-to-cortisone ratio and blood pressure in severe obesity before and after weight loss

**BACKGROUND/AIMS:** The pathogenesis of obesity-associated hypertension is poorly understood. Serum cortisol-to-cortisone ratio (F/E ratio) is a marker of cortisol metabolism. Our objective was to determine whether the serum F/E ratio is associated …

Aldosterone synthase promoter polymorphism and cardiovascular phenotypes in a large, multiethnic population-based study

**BACKGROUND:** A single-nucleotide polymorphism in the aldosterone synthase gene (CYP11B2) promoter [-344C/T, rs1799998] has been reported to associate with cardiovascular phenotypes. **METHODS:** The Dallas Heart Study is a large, multiethnic …

A critical review of the evidence supporting aldosterone in the etiology and its blockade in the treatment of obesity-associated hypertension

Obesity is epidemic and is associated with increased blood pressure, which often manifests as treatment-resistant hypertension. Mineralocorticoids have been hypothesized to have a pathogenic role in human obesity-associated hypertension. In this …