A pragmatic discussion of the diagnosis and treatment of primary aldosteronism.
Our and others' research presented at the 2018 International Society for Extracellular Vesicles' Biomarkers Workshop, Birmingham, UK.
**BACKGROUND/AIMS:** The pathogenesis of obesity-associated hypertension is poorly understood. Serum cortisol-to-cortisone ratio (F/E ratio) is a marker of cortisol metabolism. Our objective was to determine whether the serum F/E ratio is associated …
**BACKGROUND:** A single-nucleotide polymorphism in the aldosterone synthase gene (CYP11B2) promoter [-344C/T, rs1799998] has been reported to associate with cardiovascular phenotypes. **METHODS:** The Dallas Heart Study is a large, multiethnic …
Obesity is epidemic and is associated with increased blood pressure, which often manifests as treatment-resistant hypertension. Mineralocorticoids have been hypothesized to have a pathogenic role in human obesity-associated hypertension. In this …