Renin-angiotensin-aldosterone system

Current status of angiotensin receptor blocker recalls

Our analysis of data from FDA's assessment of currently marketed angiotensin receptor blocker drugs, with regard to nitrosamine impurities

Hypertension hot potato — anatomy of the angiotensin-receptor blocker recalls

We provide insights into the effects of recent blood pressure medication recalls on patients, healthcare providers, and health systems.

Primary aldosteronism

A pragmatic discussion of the diagnosis and treatment of primary aldosteronism.

Effect of bradykinin receptor antagonism on ACE inhibitor-associated angioedema

A critical review of the evidence supporting aldosterone in the etiology and its blockade in the treatment of obesity-associated hypertension

Obesity is epidemic and is associated with increased blood pressure, which often manifests as treatment-resistant hypertension. Mineralocorticoids have been hypothesized to have a pathogenic role in human obesity-associated hypertension. In this …

Pollen count and presentation of angiotensin-converting enzyme inhibitor-associated angioedema

The incidence of angiotensin-converting enzyme (ACE) inhibitor-associated angioedema is increased in patients with seasonal allergies. **OBJECTIVE:** We tested the hypothesis that patients with ACE inhibitor-associated angioedema present during …

Genetic variants associated with angiotensin-converting enzyme inhibitor-associated angioedema

**OBJECTIVE:** The objective of this study was to identify genetic variants associated with angiotensin-converting enzyme (ACE) inhibitor-associated angioedema. **PARTICIPANTS AND METHODS:** We carried out a genome-wide association study in 175 …

Association of angiotensin-converting enzyme inhibitor-associated angioedema with transplant and immunosuppressant use

**BACKGROUND:** Immunosuppressants decrease circulating dipeptidyl peptidase IV (DPPIV) activity in transplant patients, and decreased DPPIV activity has been associated with angiotensin-converting enzyme (ACE) inhibitor-associated angioedema. One …

Les effets secondaires aigus des inhibiteurs de l’enzyme de conversion de l’angiotensine dont l’angioœdème, différents dans leur étiologie clinique, partagent une physiopathologie semblable

Dipeptidyl peptidase IV in angiotensin-converting enzyme inhibitor associated angioedema

Angioedema is a potentially life-threatening adverse effect of angiotensin-converting enzyme inhibitors. Bradykinin and substance P, substrates of angiotensin-converting enzyme, increase vascular permeability and cause tissue edema in animals. …