Hypertension

Aldosterone synthase promoter polymorphism and cardiovascular phenotypes in a large, multiethnic population-based study

**BACKGROUND:** A single-nucleotide polymorphism in the aldosterone synthase gene (CYP11B2) promoter [-344C/T, rs1799998] has been reported to associate with cardiovascular phenotypes. **METHODS:** The Dallas Heart Study is a large, multiethnic …

Resistance to recommending exercise in hypertension?

Anxiety in the "age of hypertension"

In the USA, hypertension affects one in three adults, and anxiety disorders are the most commonly diagnosed mental health disorders. Both hypertension and anxiety have been studied extensively. Yet, a full understanding of anxiety's relationship to …

A controlled trial of renal denervation for resistant hypertension

**BACKGROUND:** Prior unblinded studies have suggested that catheter-based renal-artery denervation reduces blood pressure in patients with resistant hypertension. **METHODS:** We designed a prospective, single-blind, randomized, sham-controlled …

Arm position during ambulatory blood pressure monitoring: a review of the evidence and clinical guidelines

Ambulatory blood pressure monitoring (ABPM) offers advantages over clinic blood pressure measurement. Supporting the arm at the level of the right atrium has long been standard in clinic blood pressure measurement. In contrast, there is no consensus …

The contribution of the ACCOMPLISH trial to the treatment of stage 2 hypertension

The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC 7) recommended a thiazide-like diuretic, alone or in combination with other antihypertensive drug classes, as initial …

A critical review of the evidence supporting aldosterone in the etiology and its blockade in the treatment of obesity-associated hypertension

Obesity is epidemic and is associated with increased blood pressure, which often manifests as treatment-resistant hypertension. Mineralocorticoids have been hypothesized to have a pathogenic role in human obesity-associated hypertension. In this …

Detection and recognition of hypertension in anxious and depressed patients

**OBJECTIVE:** Hypertension management requires detection (i.e. confirmation of persistently high blood pressure (BP) after an initial elevated measurement) and recognition of the condition (evidenced by a formal diagnosis and/or initiation of …

Combination therapy as initial treatment for newly diagnosed hypertension

**BACKGROUND:** The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure recommends that clinicians consider the use of multidrug therapy to increase likelihood of achieving blood …

Association of angiotensin-converting enzyme inhibitor-associated angioedema with transplant and immunosuppressant use

**BACKGROUND:** Immunosuppressants decrease circulating dipeptidyl peptidase IV (DPPIV) activity in transplant patients, and decreased DPPIV activity has been associated with angiotensin-converting enzyme (ACE) inhibitor-associated angioedema. One …